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Allen C Eaves

Education
Born in Ottawa, Eaves at an early age moved to Nova Scotia. Interested in science, attended Acadia University and graduated with a degree in Biology and Mathematics in 1962. He then moved to Dalhousie University and completed his master's degree in cell physiology with Dr. Gordon Kaplan Radiology in an investigation of two systems of cellular enzymes, Yeast (1964). The premature death of cancer of a family friend took him to switch to medicine, completing his doctoral internship in 1969. During his medical studies he was strongly influenced by Dr. Ross Langley, a hematologist-oriented research Eaves suggests that doing a PhD at the Princess Margaret Hospital in Toronto, where Dr. Robert Bruce was working with Drs. James Till and Ernest McCulloch (Lasker Award) on how different types of cancer chemotherapeutic agents kill tumor stem cells without affecting normal stem cells.
Working under the supervision of Bruce (AACR Award), and in partnership with Till and McCulloch and a vibrant group of graduate students and postdocs, Eaves completed his PhD in Biophysics Medical University of Toronto with a thesis entitled Studies on the control of murine bone marrow function (1974). Eaves then decided to complete their training clinical specialist in Internal Medicine and Medical Oncology in Canada that could be licensed to work in Canada and have access to human material for the study of leukemia in humans directly, rather than in mice. He received this clinical education in Toronto and Vancouver, becoming a member of the College Royal of Physicians and Surgeons (FRCPC) in 1979 and member of the American College of Physicians (FACP) in 1980. He then joined the staff of the British Columbia Cancer Agency (BCCA), Vancouver General Hospital and the University of British Columbia in 1979 as assistant professor, becoming associate professor in 1984, professor in 1989 and Professor Emeritus of Hematology in 2006.
Race
In 1981, as one of the first students of the BC Health Research Foundation, founded the Laboratory Eaves Terry Fox Hematology. As Director of the TFL in the next 25 years, built the TFL in a group of internationally renowned research staff of more than one 150 including 13 senior scientists, 35 graduate students and 40 post-doctoral (www.bccrc.ca / TfL). The TFL is a leader in understanding the regulation of hematopoietic (blood forming) stem growth and differentiation. The TFL played a leadership role in obtaining the grant that started TPI funding for the new $ 100 million, 15 plants, BC Cancer Research Center (opened on March 1, 2005), where the TFL occupies the top several floors of this facility art. Eaves personal research has focused on leukemia in which ulture purge pioneered a new approach to autologous bone marrow transplantation marrow to chronic myelogenous leukemia. It has more than 200 articles in leading journals of scientific peer review. In 2003 he was awarded the prestigious RM Taylor Medal by the Canadian Cancer Society and National Cancer Institute of Canada.
In 1985 he became head of Hematology Eaves at UBC, VGH BCCA and where during the next 18 years focused on the construction of the first class Leukemia / Bone Marrow Transplantation (BMT) Program of British Columbia. This was one of the programs of bone marrow transplantation for the first time in Canada, and the beginning of 1990 more than 1500 patients were transplanted of which 300 came from other provinces (BC revenue generating more than $ 30 million). The program also trained a significant number of specialists bone marrow transplant, many of whom have played a role in the initiation of programs for bone marrow transplant in other parts of Canada and abroad. In recognition of its interests in the bone marrow transplant was elected President of the International Society for Cellular Therapy (1995-1997), President of the American Society Transplantation of Blood and Marrow (1999-1900) and Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995-2002). It has also been a member of Health Canada Working Group of Experts on the safety of organs and tissues for transplantation, and the Canadian Standards Association Working Group to develop standards and an accreditation process of cell therapy and transplantation in Spain (1998-2006).
In 1980, to raise money to keep running the Terry Fox Laboratory, Eaves sold erythropoietin urinary and tissue culture reagents to research colleagues around the world. In early 1990 it became necessary to make the tissue culture media in a clean room. However, the BC Cancer Foundation did not have the $ 1 million needed to build these facilities and Eaves encouraged to buy the business from them and raise the money himself, what made through the full mortgage his house and get a loan from Western Economic Diversification. As of 8 employees in 1993, stemcell Technologies Inc has grown to 20 to 30% year and in January 2010 had over 320 employees. Stemcell is the largest biotechnology company in British Columbia in terms of employees based in British Columbia. There are 800 products in its catalog, and drove to all production at its plant in Vancouver. Stemcell is still profitable with 2010 sales of $ 50 million. A company internationally competitive and export-oriented, 95% of its customers are outside of Canada. In addition to its facilities in Vancouver, has distribution stemcell and sales offices in the U.S., Europe, Australia and Singapore, more distributors in all other countries. A spin-off company, STEMSOFT Software Inc, makes software for data management in the centers of bone marrow transplant, blood bank of umbilical cord cell therapy companies and the tumor / tissue repositories. A second spin-off, Malachite Management Inc, is the holding and management of meetings for organizations such as the Canadian Blood and Marrow Transplant Group, the International Society Cell Therapy, the American Society for Apheresis and the Canadian Association of Nurses in Oncology. From 2010, the Group had 260 employees stemcell in Vancouver, most of which are located in Building 570 stemcell West Seventh Avenue. It should be noted that stemcell Technologies Inc supports Networks of Centres of Excellence Canada (NCE) program, including: the Stem Cell Network, where stemcell Technologies Inc is the leading supporter and eaves is a member of the Board, and Mathematics Information Technology and Complex Systems, where Eaves is the Chairman of the Board of Directors. Eaves is passionate about helping British Columbia become in a culture more oriented to science and the economy that is knowledge based, high technology and the environment.
Honours
National Institute Canadian Cancer Fellowship, 1979-1974
Research Fellow of the Foundation of British Columbia Health Care Research, 19791983
Student Distinguished Service Award, Acadia University, 1997
Hematology Polish National Society Medal, 2000
Distinguished Chair of Medicine Award, University of British Columbia, 2001
RM Taylor Medal, Canadian Cancer Society and National Cancer Institute of Canada, 2002
Lifetime Membership Award International Society for Cellular Therapy, 2002
Genome BC Award for Scientific Excellence (Co-recipient with Dr. Connie Eaves), 2007
References
http://www.biv.com/publications/spbiobc.asp ^
Coulombel l et al. Growing long-term marrow reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome positive chronic myelogenous leukemia. N Engl J Med 308:1493-1498, 1983.
Eaves AC, et al. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells. Proc Natl Acad Sci USA 83: 5306-5310, 1986.
Barnet MJ et al. Successful autografting in AML chronic after repair of the bone in culture. Bone Marrow Transplant 4: 345-351, 1989.
CJ Eaves and AC Eaves. Erythropoietin (EP) the dose-response curves for three classes of erythroid progenitors in normal conditions and in patients with polycythemia vera. Blood: 52 1196-1210, 1978.
Cashman JD, et al. Unregulated proliferation of primitive neoplastic progenitor cells in long-term cultivation of polycythemia vera marrow. J Clin Invest 81:87-91, 1988.
Hogge DE, L Coulombel, Kalousek DK, Eaves CJ & Eaves AC. No clonal hemopoietic progenitors in a G6PD heterozygote with chronic myelogenous leukemia after growing bone marrow revealed the long term. Am J Hematol 24: 389-394, 1987.
Hogge DE, Shannon KM, Kalousek DK, Schonberg S, V Schaffner, S Zoger, Eaves CJ and Eaves AC. Juvenile monosomy 7 syndrome: Evidence that the disease originates in a pluripotent hematopoietic stem cells. Leuk Res 11: 705-709, 1987.
Turhan AG, Humphries RK, Cashman JD, Cuthbert DA, CJ Eaves and AC Eaves. Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder. J Clin Invest 81: 1999-2003, 1988.
Barnett MJ, Eaves CJ, DK Phillips GL, Kalousek, Klingemann HG, Lansdorp PM, Reece DE, Shepherd JD, Shaw GJ and AC Eaves. The success of autografting in chronic myeloid leukemia after repair of the bone in culture. Bone Marrow Transplant 4: 345-351, 1989.
Barnett MJ, Eaves CJ, DK Phillips GL, Kalousek, HG Klingemann, PM Lansdorp, Reece DE, Shepherd JD, Shaw GJ and AC Eaves. Successful autografting in chronic myeloid leukemia after bone repair in culture. Bone Marrow Transplant 4: 345-351, 1989.
Szilvassy SJ, CC Fraser, CJ Eaves, PM Lansdorp, AC Eaves & RK Humphries. Retrovirus mediated gene transfer of hematopoietic stem cells purified with long-term repopulating ability lymph myelopoietic. Proc Natl Acad Sci USA 86: 8798-8802, 1989.
AG Turhan, RK Humphries, GL Phillips, AC Eaves & CJ Eaves. Clonal hematopoiesis demonstrated by DNA polymorphisms linked to the X after allogeneic bone marrow. N Engl J Med 320: 1655-1661, 1989.
HJ Sutherland, PM Lansdorp, DH Henkelman, AC Eaves & CJ Eaves. Functional characterization of the different in cultured human cells in the bone marrow hematopoietic stem support limiting dilution stromal layers. Proc Natl Acad Sci USA 87: 3584-3588, 1990.
Szilvassy SJ, RK Humphries, PM Lansdorp, AC Eaves & CJ Eaves. Quantitative assay for totipotent reconstituting hematopoietic stem cells in a recruitment strategy competitive. Proc Natl Acad Sci USA 87: 8736-8740, 1990.
Turhan AG, Humphries RK, Eaves CJ, Barnett MJ, Phillips GL, Kalousek DK, Klingemann HG, Lansdorp PM, Reece DE, JD Shepherd and AC Eaves. Detection of hematopoiesis breakpoint cluster region and not negative clonal in vitro and in vivo after transplantation of cells selected marrow cultures in chronic myeloid leukemia. Blood 76: 2404-2410, 1990.
Udomsakdi C, Eaves CJ, B Swolin, DS Reid, MJ Barnett and AC Eaves. The rapid decline of chronic myeloid leukemia cells in long-term culture due to a defect in the leukemic stem cell level. Proc Natl Acad Sci USA 89: 6192-6196, 1992.
CJ Eaves, JD Cashman, SD Wolpe and AC Eaves. Lack of response of primitive cells of chronic myeloid leukemia with the 1st macrophage inflammatory protein an inhibitor of primitive normal hematopoietic cells. Proc Natl Acad Sci USA 90: 12015-12019, 1993.
AL Petzer, CJ Eaves, PM Lansdorp, L Ponchi, MJ Barnett and eaves AC. Characterization of primitive subpopulations of normal and leukemic cells in the blood of patients with newly diagnosed leukemia and establish chronic myeloid. Blood 88: 2162-2171, 1996.
Cashman JD, Eaves CJ AH, Sarris and AC Eaves. MCP-1, MIP-1a is the endogenous chemokine that cooperates with TGF-b to inhibit cycling of primitive normal but not leukemic (CML) in cultures of human marrow progenitor cells in the long term. Blood 92: 2338-2344, 1998.
Jiang X, Lopez A, Holyoake T, Eaves A & C. Eaves Autocrine production and action of IL-3 and colony-stimulating factor of granulocytes in chronic myeloid leukemia. Proc Natl Acad Sci USA 96: 12804-12809, 1999.
Jiang X, Fujisaki T, Nicolini F, Berger M, Holyoake T, W Eisterer, Eaves C & A. Eaves Autonomous multi-lineage differentiation in vitro of primitive CD34 + cells from patients with chronic myeloid leukemia. Leukemia 14: 1112-1121, 2000.
Holyoake TL, Jiang X, Jorgensen HG, MJ Graham S, Alcorn, C Laird, AC Eaves & CJ Eaves. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor in vitro growth independent association with up-regulation of expression of interleukin-3. Blood 97: 720-728, 2001.
Cashman J, Dykstra B, Clark-Lewis I, eaves of A & C. Eaves Changes in the proliferative activity of hematopoietic stem cells in NOD / SCID mice and enhancement of their transplants later in vivo treatment with inhibitors the cell cycle. J Exp Med 196: 1141-1149, 2002.
Jiang X, Zhao Y, Chan WY, Vercauteren S, Pang E, Kennedy S, Nicolini F, Eaves A & C. Eaves expression Deregulation in Ph + human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia. Blood 103: 3897-3904, 2004.
INTERNAL LINKS WIKIPEDIA
Even James
Ernest McCulloch
Connie Eaves
Stem Cells
Hematopoiesis
Hematopoietic stem cells
Cellular therapy
Bone Marrow Transplantation
Chronic myelogenous leukemia
Polycythemia vera
Terry Fox Laboratory
BC Cancer Research Center
BC Cancer Agency
External Links
Leukemia / Bone Marrow Transplant Program of British Columbia Bone
Canadian Cancer Society
Stemcell Technologies Inc
STEMSOFT Software Inc
Malachite Management Inc
Mathematics of Information Technology and Complex Systems
With Canadian Stem Cell Network
Bruce Robert AM. Assoc. Prize for Cancer Research
James Till and Ernest McCulloch Lasker Award
International Society Cellular Therapy (ISCT)
American Society for Blood and Marrow Transplantation Bone (ASBMT)
Foundation for the Accreditation of Cellular Therapy (FACT)
Cell Therapy News
Categories: stem cell researchers | Canadian medical researchers | Cancer researchers | Living peopleHidden categories: All articles with unsourced statements | Articles lacking reliable references from January 2010 About the Author

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